I have used this brand with Blue for a year now, it is the only thing that keeps him from drooling and vomiting on car rides. I can say that my husband has been sharing it with him and neither have had any ill effects. My co-workers also use this with their dogs and none of them have had any problems either. We are very careful about what we give Blue and check all of the websites and FDA lists before we give him anything and most of our treats are made fresh in our own kitchen, but he does eat the jerky on a daily basis.