We had Cleo and Jasmine on Deramaxx for a long time. It was hard to tell how it worked for Cleo, but Jasmine really responded well with it. She would only use three legs and she couldn't squat because of her arfritus and the Deramaxx got her back on all 4 legs. We always gave it to them with their dinner to avoid upset tummys. I don't know how everyone else gives pills, but we like to put a little spray cheese on our finger and put the pill in it. They lick it off. With Jasmine it took a while to train her to not take your finger with it, but she learned. For a while she had the nickname of Pirahna. Sometimes we would use peanut butter if they spit the pill out as it is harder for them to spit it out.