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Wish I had some "sage advice", but since fleas are NOT a problem in this area, I've never had to use any flea treatments on my pack. Thankfully, we have neither fleas or heartworms - both of which I had to deal with in Sacramento. I did have one "rescue" come to me from West Virginia - she was "loaded" - and vet treated her wtih Frontline. None of the others were infected by her though.